a CAS Framework for Predicting the Synthetic Evolution of Anti-Plastic Enzymes

6. Visualization 

Graph networks of residue-residue contacts overlaid with G shifts.

Mutation tree maps, showing convergence/divergence clusters.

3D structure overlays (WT vs. V199), highlighting active site reshaping.

Trajectory heatmaps, mapping G_folding vs. G_binding evolution.

7. Significance

Even in a dummy, synthetic context, the simulation:

Reproduces known mutation benefits in PETase (validating framework)

Suggests novel candidates (e.g., G116S) worth in vitro validation

Demonstrates the scalability and nuance of the CAS-based engine

Lays groundwork for more advanced AI-in-the-loop, data-augmented evolutionary design